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Use of serum specimens Decisions about tests to be performed on these specimens will be made by the members of the NSABP Breast Committee and consulting researchers with expertise in this area. Collected sera at baseline will be used for proteomics studies in order to examine protein markers or entire serum proteins ; that may be prognostic and or predictive of response to regimens used in the study. Sera collected at subsequent timepoints will be used for proteomics studies in order to examine protein markers that may be predictive of relapse or new primary breast cancers. Since the field of proteomics is rapidly evolving, we are not yet committed to any one methodology. At the end of the trial, the best methodologies will be identified and employed.

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