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1. Moreno R, Fernandez C, Alfonso F, Hernandez R, Perez-Vizcayno MJ, Escaned J et al. Coronary stenting versus balloon angioplasty in small vessels: a meta-analysis from 11 randomized studies. J Coll Cardiol. 2004; 43: 1964-72. Ardissino D, Cavallini C, Bramucci E, Indolfi C, Marzocchi A, Manari A et al. Sirolimus-eluting vs uncoated stents for prevention of restenosis in small coronary arteries: a randomized trial. JAMA. 2004; 292: 2727-34. Holmes DR Jr, Kereiakes DJ. The approach to small vessels in the era of drug-eluting stents. Rev Cardiovasc Med. 2005; 6 Suppl 1: S31-7. Saucedo JF, Popma JJ, Kennard ED, Talley JD, Lansky A, Leon MB et al. Relation of coronary artery size to one-year clinical events after new device angioplasty of native coronary arteries a New Approach to Coronary Intervention [NACI] Registry Report ; . J Cardiol. 2000; 85: 166-71. Schampaert E, Cohen EA, Schluter M, Reeves F, Traboulsi M, Title LM et al. The Canadian study of the sirolimus-eluting stent in the treatment of patients with long de novo lesions in small native coronary arteries C-SIRIUS ; . J Coll Cardiol. 2004; 43: 1110-5. Devito FS, Sousa AGMR, Feres F, Abizaid A, Staico R, Mattos LAP et al. Comparative Analysis of Intimal Hyperplasia After Sirolimus-Eluting Stent and Thin-Strut Bare Metal Stent Implantation in Small Coronary Arteries. Arq Bras Cardiol. 2006; 86: 268-75. Regar E, Serruys PW, Bode C, Holubarsch C, Guermonprez JL, Wijns W et al. Angiographic findings of the multicenter Randomized Study With the Sirolimus-Eluting Bx Velocity Balloon-Expandable Stent RAVEL ; : sirolimus-eluting stents inhibit restenosis irrespective of the vessel size. Circulation. 2002; 106: 1949-56. Moses JW, Leon MB, Popma JJ, Fitzgerald PJ, Holmes DR, O'Shaughnessy C et al. Sirolimus-eluting stents versus standard stents in patients with stenosis in a native coronary artery. N Engl J Med. 2003; 349: 1315-23. Popma JJ, Leon MB, Moses JW, Holmes DR Jr, Cox N, Fitzpatrick M et al. Quantitative assessment of angiographic restenosis after sirolimuseluting stent implantation in native coronary arteries. Circulation. 2004; 110: 3773-80. Schofer J, Schluter M, Gershlick AH, Wijns W, Garcia E, Schampaert E et al. Sirolimus-eluting stents for treatment of patients with long atherosclerotic lesions in small coronary arteries: double-blind, randomised controlled trial E-SIRIUS ; . Lancet. 2003; 362: 1093-9. Nikolsky E, Moses JW, Cambier P Bachinsky B, O' Shaughnessy , C, Mehran R et al. Results from the 2.25mm Sirolimus-Eluting BS Velocity Stent Registry in Patients with Native Coronary Artery Lesions. J Cardiol. 2005; 96 Suppl 7A ; : 179H. 12. Ortolani P Ardissino D, Cavallini C, Bramucci E, Indolfi C, Aquilina , M et al. Effect of sirolimus-eluting stent in diabetic patients with small coronary arteries a SES-SMART substudy ; . J Cardiol. 2005; 96: 1393-8. Moussa I, Leon MB, Baim DS, O'Neill WW, Popma JJ, Buchbinder M et al. Impact of sirolimus-eluting stents on outcome in diabetic patients: a SIRIUS SIRolImUS-coated Bx Velocity balloon-expandable stent in the treatment of patients with de novo coronary artery lesions ; substudy. Circulation. 2004; 109: 2273-8. Lemos PA, Arampatzis CA, Saia F, Hoye A, Degertekin M, Tanabe K et al. Treatment of very small vessels with 2.25-mm diameter sirolimus-eluting stents from the RESEARCH registry ; . J Cardiol. 2004; 93: 633-6. Sousa JE. SVELTE: Multicenter, Controlled Study of Sirolimus-Eluting Stents in Small Vessels. Transcatheter Cardiovascular Therapeutics TCT ; , Washington, DC [presentation]. : tctmd csportal appmanager tctmd main? nfpb true& pageLabel TCTM DContent&hdCon 814312. 2004. 16. Lemos PA, Saia F, Ligthart JM, Arampatzis CA, Sianos G, Tanabe K et al. Coronary restenosis after sirolimus-eluting stent implantation: morphological description and mechanistic analysis from a consecutive series of cases. Circulation. 2003; 108: 257-60. Iakovou I, Mintz GS, Dangas G, Abizaid A, Mehran R, Lansky AJ et al. Optimal final lumen area and predictors of target lesion.
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Goldsmith, P., K. Rossiter, A. Carter, C. G. Unson, R. Vinitsky, and A. M. Spiegel 1988 ; Identification of the GTP-binding protein encoded for by G , complementary DNA. J. Biol. Chem. in press ; . Harris-Warrick, R. M., C. Hammond, D. Paupardin-Tritsch, V. Homburger, B. Rouot, J. Bockaert, and H. Gerschenfeld 1988 ; An o ~ subunit of GTP-binding protein immunologically related to G, mediates a dopamine-induced decrease of Ca + current in snail neurons. Neuron I: 27-32. Hescheler, J., W. Rosenthal, W. Trautwein, and G. Schultz 1987 ; The GTP-binding protein, G regulates neuronal calcium channels. Nature 325: 445447. Hill, D. R., N. G. Bowery, and A. L. Hudson 1984 ; Inhibition of GABA, receptor binding by guanyl nucleotides. J. Neurochem. 42: 652-657. Hoehn, K., A. Reid, and J. Sawynok 1988 ; Pertussis toxin inhibits antinociception produced by intrathecal injection of morphine, noradrenaline and baclofen. Eur. J. Pharmacol. 146: 65-72. Holz, G. G. IV, R. M. Kream, and K. Dunlap 1985 ; Norepinephrine inhibits field stimulation-evoked release of substance P from chick dorsal root ganglion cells in culture. Sot. Neurosci. Abstr. II: 126. Holz, G. G. IV, S. G. Rane, and K. Dunlap 1986a ; GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels. Nature 319: 670-672. Holz, G. G. IV, K. Dunlap, and R. M. Kream 1986b ; Pertussis toxinsensitive GTP-binding proteins couple alpha-2. adrenergic and GABA-B receptors to inhibition of neurosecretion in dorsal root ganglion cells. Sot. Neurosci. Abstr. 12: 1195. Holz, G. G. IV, K. Dunlap, and R. M. Kream 1988 ; Characterization of the electrically-evoked release of substance P from dorsal root ganglion neurons: Methods and dihydropyridine sensitivity. J. Neurosci. 8: 463-47 1. Howe, J. R., T. L. Yaksh, and V. L. W. 1987 ; The effects of unilateral dorsal root ganglionectomies or ventral rhizotomies on LY * adrenoreceptor binding to, and the substance P, enkephalin, and neurotensin content of, the cat lumbar spinal cord. Neuroscience 21: 385394. Howell, T. W., S. Co&oft, and B. D. Gomperts 1987 ; Essential synergy between Ca * + and guanine nucleotides in exocytotic secretion from permeabilized rat mast cells. J. Cell Biol. 105: 19 l-l 97. Jones, D. T., and R. R. Reed 1987 ; Molecular cloning of five GTPbinding protein of cDNA species from rat olfactory neuroepithelium. J. Biol. Chem. 262: 14241-14249. Katada, T., M. Oinuma, K. Kusakabe, and M. Ui 1987 ; A new GTPbinding protein in brain tissues serving as the specific substrate of islet-activating protein, pertussis toxin. FEBS Lett. 213: 353-358. Knight, D. E., and P. F. Baker 1985 ; Guanine nucleotides and Cadependent exocytosis. FEBS Lett. 189: 345-349. Kream, R. M., T. A. Schoenfeld, R. Mancuso, A. Clancy, W. El-Bermani, and F. Macrides 1985 ; Precursor forms of substance P SP ; in nervous tissue: Detection with antisera to SP, SP-Gly, and SP-GlyLys. Proc. Natl. Acad. Sci. USA 82: 4832-4836. Kuraishi, Y., N. Hirota, Y. Sato, S. Kaneko, M. Satoh, and H. Takagi 1986 ; Noradrenergic inhibition of the release of substance P from the primarv afferents in the rabbit sninal dorsal horn. Brain Res. 359: 177-182.
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Instituto Nazionale per la Fauna Selvatica, Via C Fornacetta, 9 40064 Ozzano Emilia BO ; , Italy; e-mail: grill science.uva.nl The red squirrel, Sciurus vulgaris, has declined dramatically in Europe during the last century. However, phylogeographic data covering its entire distribution area, which provide the basis to identify the evolutionary significant units of this species and to establish an effective conservation strategy on a European scale, are still missing. We sequenced parts of the mitochondrial DNA gene D-Loop and cytochrome b ; of S. vulgaris from Southern, Central, Eastern and Western Europe, including locations from the Alps, Apennines, the Balkans and European Russia, in order to assess genetic variation and differentiation of this species across its European distribution. The data collected is used to infer past demographic changes and reconstruct the history of the species since the last glacial maximum. Finally, these data will be used to define conservation units of populations of the red squirrel and provide practical recommendations for its management in order to prevent further decline.
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Figure D.4-1, Flight 10A Node 2 Topology, shows a high level overview of the Node 2 on-orbit topology at the beginning of the increment. Refer to Table D.2-1 for a definition of the rack SE numbers and axert
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Choice of the metal ion, solvent mixture, and pH allows an almost limitless number of modifications of excited-state properties, such as phosphorescence quantum yield, phosphorescence emission maxima, and phosphorescence lifetimes. In Table 9, the effect of silver ion on a number of nucleosides and DNA is shown. Enhancement of the limits of detection and selective quenching are both demonstrated in the case of Ag-ligand interactions. As the behavior of inorganic probes becomes better understood, it should be possible to introduce one metal ion to quench the phosphorescence of one species and another metal ion to enhance the phosphorescence of a second species thereby selecting a particular analyte in complex mixtures. Studies of other metal ions and ligand systems indicate that such an approach is indeed tenable.3 and azacitidine.
Sequences were taken from the SWISSPROT protein sequence database release 21; Bairoch & Boeckmann, 1992 ; or from the literature. the identifiers are given in TaAll ble l . Sequences from sources other than SWISSPROT are: rat hexokinases type I1 Hxk2 Rat; Thelen & Wilson, 1991 ; and type 111 Hxk3 Rat; Schwab & Wilson, 1991 ; , human liver glucokinases Hxkh Human; Tanizawa et al., 1991 ; , mouse pituitary glucokinase Hxkp Mouse; Hughes et al., 1991 ; , a fragment of a putative isoenzyme of human brain hexokinase Hxst Human; Adams et al., 1992 ; , liver cattle hexokinase Hxkc Bovin; EMBL accession number.
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